Hereditary cancer is defined as cancer that has been caused by an inherited genetic variant. The Hereditary Cancer Panel involves testing for inherited genetic variants that are associated with an increased cancer susceptibility risk.

The Hereditary Cancer Panel includes 31 different genes and has been expertly curated using current literature and national testing guidelines to maximise clinical actionability, whilst minimising uncertainty. This multi-cancer panel targets genes associated with breast, ovarian, colorectal, prostate, melanoma, and pancreatic cancer.

The full gene list for this panel is shown below:

APC, ATM, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, HOXB13, MLH1, MSH2, MSH6, MUTYH, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53, VHL.